Snow Medical

Michelle will aim to transform our understanding of immune development to malaria by using best unique human samples and cutting-edge technologies.

Arnold applies engineering principles to understand the cardiovascular system at molecular and cellular scales, leading the development of microtechnologies to pick up early signs of heart attack or stroke.

Using structural biology to unravel the molecular mechanisms involved in bacterial immune systems and to apply this to development of next generation RNA based biomedical tools.

Investigating how and why disruption of the cellular RNA messenger factory leads to cancer, and which components should be targeted to improve treatments for cancers with poor outcomes.

Illuminating how currently invisible non coding elements of the “dark genome” function in health and disease and how they can be manipulated to transform our understanding of heart disease and the complex mechanics of ageing.

Genomic and clinical approaches targeting individual patient and population differences in pancreatic cancer progression, chemotherapy, and drug resistance to inform the design of new, more effective tailored treatment options.

Uncovering how loss of control of cell type and function leads to cancer progression, and applying this to discovery of new prognostic markers and therapeutics.

Investigating how cancers evade and become resistant to drug treatment with a focus on developing and trialling new drug therapies.

Harnessing the human immune system to develop new immunotherapies that can target and eradicate cancer.

Large-scale population and individual patient genomics to improve diagnosis and treatment of severe inherited, autoimmune and inflammatory diseases.

Engineering a synthetic heart model to rapidly advance understanding of the biological processes regulating cardiac biology and heart disease and discovery of new therapeutics.